Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition
نویسندگان
چکیده
منابع مشابه
Severe lactic acidosis reversed by thiamine within 24 hours
iamine is a water-soluble vitamin that plays a pivotal role in carbohydrate metabolism. In acute defi ciency, pyruvate accumulates and is metabolized to lactate, and chronic defi ciency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients [1]. Critically ill patients are prone to t...
متن کاملSelenium deficiency during total parenteral nutrition--a case report.
THE trace element selenium has recently been recognised as an essential constituent of the enzyme glutathione peroxidase (GSHPx, EC 1.11.1.9) which is thought to have a major function in the removal of hydrogen peroxide and other organic hydroperoxides generated during oxidative metabolism.' Both selenium and vitamin E appear to protect against a myopathic condition seen in young animals put to...
متن کاملHyperglycemia During Total Parenteral Nutrition
OBJECTIVE To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome. RESEARCH DESIGN AND METHODS The study determined whether blood glucose values before, within 24 h, and during days 2-10 of TPN are predictive of hospital complications and mortality. RESULTS Subjects included a total of 276 patients receiving TPN for a mean duration of 15 +/- 24 ...
متن کاملType B lactic acidosis secondary to thiamine deficiency in a child with malignancy.
Type B lactic acidosis is an underrecognized clinical entity that must be distinguished from type A (hypoxic) lactic acidosis. We present the case of a 4-year-old boy with medulloblastoma who presented with lactic acidosis in the setting of septic shock. His hyperlactatemia persisted to high levels even after his hemodynamic status improved. After administration of intravenous thiamine, his lac...
متن کاملThiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient
Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, ...
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ژورنال
عنوان ژورنال: Case Reports
سال: 2014
ISSN: 1757-790X
DOI: 10.1136/bcr-2014-205264